Settore ERC

LS4_7 - Cardiovascular diseases
LS5_8 - Behavioral neuroscience



Research activity in the Stress Physiology Lab is mainly focused on the biological substrates of depression/anxiety and autonomic/cardiovascular dysfunction comorbidity. This topic is approached via preclinical research on animal models of depression (based on adverse social conditions) and anxiety (based on lines selectively bred). Proendocannabinoid pharmacological treatment (FAAH inhibition) is tested to verify its pevention/reversal potential over behavioral and physiological symptoms of anxiety/depression as well as over autonomic/cardiovascular dysfunction. Part of the lab research activity is also devoted to the evaluation of a number of chronic stress parameters in various human populations.


Stress, chronic social stress, biological stress markers, anxiety, depression, coping styles, social behavior, hypothalamic-pituitary-adrenocortical axis, sympathetic-adrenomedullary system, autonomic nervous system, heart rate variability, cardiovascular physiology and pathophysiology, arrhythmias, rodent model of empathy




Prodotti della ricerca



Tobaldini, E., Carandina, A., Toschi-Dias, E., Erba, L., Furlan, L., Sgoifo, A., Montano, N. Depression and cardiovascular autonomic control: a matter of vagus and sex paradox. Neuroscience and Biobehavioral Reviews
Volume 116, September 2020, Pages 154-161

Sgoifo, A., Carnevali, L., Pattini E, Carandina, A., Tanzi, G., Del Canale, C., Goi, P., De Felici del Giudice, M.B., De Carne, B., Fornari, M., Gavazzoli, B., Poisa, L., Manzoni, D., Bollati, D. 
Psychobiological evidence of the stress resilience fostering properties of a cosmetic routine. Stress. 2020 Apr 10:1-1

Carnevali L, Statello R, Vacondio F, Ferlenghi F, Spadoni G, Rivara S, Mor M, Sgofio. A. Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats. European Neuropsychopharmacology
32, Pages 77-87, 2020

Carnevali L, Montano N, Tobaldini E, Thayer JF, Sgoifo A. The contagion of social defeat stress: Insights from rodent studies. Neuroscience and Biobehavioral Reviews
Volume 111, April 2020, Pages 12-18

Carnevali L, Montano N, Tobaldini E, Thayer JF, Sgoifo A.Neurosci Biobehav Rev. 2020 Apr;111:12-18. doi: 10.1016/j.neubiorev.2020.01.011. Epub 2020 Jan 10.PMID: 31931035 Review.

Carnevali L, Pattini E, Sgoifo A, Ottaviani C. (2019) Effects of prefrontal transcranial direct current stimulation on autonomic and neuroendocrine responses to psychosocial stress in healthy humans. Stress 8:1-11

Carnevali L, Statello R, Sgoifo A. (2019) Resting Heart Rate Variability Predicts Vulnerability to Pharmacologically-Induced Ventricular Arrhythmias in Male Rats. Journal of Clinical Medicine 8(5):pii: E655

Pattini E, Carnevali L, Troisi A, Matrella G, Rollo D, Fornari M, Sgoifo A. (2019) Psychological characteristics and physiological reactivity to acute stress in mothers of children with Autism Spectrum Disorder. Stress & Health

Statello R, Carnevali L, Bianchi S, Sgoifo A, Imeri L. (2019) Febrile and sleep responses to an immune challenge are affected by trait aggressiveness in rats.  Brain Behavior Immunity 80:300-307

Williams DP, Koenig J, Carnevali L, Sgoifo A, Jarczok MN, Sternberg EM, Thayer JF. (2019) Heart Rate Variability and Inflammation: A Meta-Analysis of Human Studies. Brain, behavior, and immunity [DOI  PMID]

Huzard D, Ghosal S, Grosse J, Carnevali L, Sgoifo A, Sandi C. (2019) Low vagal tone in two rat models of psychopathology involving high or low corticosterone stress responses. Psychoneuroendocrinology 101 101-110 [DOI  PMID]

Statello R, Carnevali L, Alinovi D, Pisani F, Sgoifo A. (2018) Heart rate variability in neonatal patients with seizures. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 129(12) 2534-2540 [DOI  PMID]

Carnevali L, Statello R, Sgoifo A. (2018) The Utility of Rodent Models of Stress for Disentangling Individual Vulnerability to Depression and Cardiovascular Comorbidity. Current cardiology reports 20(11) 111 [DOI  PMID]

Carnevali L, Koenig J, Sgoifo A, Ottaviani C. (2018) Autonomic and Brain Morphological Predictors of Stress Resilience. Frontiers in neuroscience 12 228 [DOI  PMID]

Fornari M, Carnevali L, Sgoifo A. (2017) Single Osteopathic Manipulative Therapy Session Dampens Acute Autonomic and Neuroendocrine Responses to Mental Stress in Healthy Male Participants. The Journal of the American Osteopathic Association 117(9) 559-567 [DOI  PMID]

Carnevali L, Montano N, Statello R, Coude G, Vacondio F, Rivara S, Ferrari PF, Sgoifo A. (2017) Social stress contagion in rats: Behavioural, autonomic and neuroendocrine correlates. Psychoneuroendocrinology 82 155-163 [DOI  PMID]

Carnevali L, Montano N, Statello R, Sgoifo A. (2017) Rodent models of depression-cardiovascular comorbidity: Bridging the known to the new. Neuroscience and biobehavioral reviews 76(Pt A) 144-153 [DOI  PMID]

Rossi S, Buccarello A, Ershler PR, Lux RL, Callegari S, Corradi D, Carnevali L, Sgoifo A, Miragoli M, Musso E, Macchi E. (2017) Effect of anisotropy on ventricular vulnerability to unidirectional block and reentry by single premature stimulation during normal sinus rhythm in rat heart. American journal of physiology. Heart and circulatory physiology 312(3) H584-H607 [DOI  PMID]

Villada C, Espin L, Hidalgo V, Rubagotti S, Sgoifo A, Salvador A. (2017) The influence of coping strategies and behavior on the physiological response to social stress in women: The role of age and menstrual cycle phase. Physiology & behavior 170 37-46 [DOI  PMID]

Sgoifo A, Montano N, Esler M, Vaccarino V. (2017) Stress, behavior and the heart. Neuroscience and biobehavioral reviews 74(Pt B) 257-259 [DOI  PMID]

Carnevali L, Andrews PL, Neumann ID, Nalivaiko E, Sgoifo A. (2016) Autonomic changes induced by provocative motion in rats bred for high (HAB) and low (LAB) anxiety-related behavior: Paradoxical responses in LAB animals. Physiology & behavior 167 363-373 [DOI  PMID]

Statello R, Carnevali L, Paterlini S, Gioiosa L, Bertocchi I, Oberto A, Eva C, Palanza P, Sgoifo A. (2017) Reduced NPY Y1 receptor hippocampal expression and signs of decreased vagal modulation of heart rate in mice. Physiology & behavior 172 31-39 [DOI  PMID]

Walker FR, Pfingst K, Carnevali L, Sgoifo A, Nalivaiko E. (2017) In the search for integrative biomarker of resilience to psychological stress. Neuroscience and biobehavioral reviews 74(Pt B) 310-320 [DOI  PMID]

Carnevali L, Rivara S, Nalivaiko E, Thayer JF, Vacondio F, Mor M, Sgoifo A. (2017) Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity? Neuroscience and biobehavioral reviews 74(Pt B) 444-452 [DOI  PMID]

Carnevali L, Vacondio F, Rossi S, Macchi E, Spadoni G, Bedini A, Neumann ID, Rivara S, Mor M, Sgoifo A. (2015) Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety. Scientific reports 5 18218 [DOI  PMID]

Carnevali L, Vacondio F, Rossi S, Callegari S, Macchi E, Spadoni G, Bedini A, Rivara S, Mor M, Sgoifo A. (2015) Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 25(11) 2157-69 [DOI  PMID]

Sgoifo A, Carnevali L, Alfonso Mde L, Amore M. (2015) Autonomic dysfunction and heart rate variability in depression. Stress (Amsterdam, Netherlands) 18(3) 343-52 [DOI  PMID]

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