Prof. Nicola Della Ca'

Professore Associato

Pubblicazioni selezionate

Voronov, A , Botla, V , Montanari, L , Carfagna, C , Mancuso, R , Gabriele, B , Maestri, G , Motti, E , Della Ca', , N (2022)
Pd-Catalysed oxidative carbonylation of α-amino amides to hydantoins under mild conditions.
Mancuso, R , Strangis, R , Ziccarelli, I , Della Ca', N , Gabriele, B (2021)
Palladium catalysis with sulfurated substrates under aerobic conditions: A direct oxidative carbonylation approach to thiophene-3-carboxylic esters.
Mancuso, R , Ziccarelli, I , Brindisi, M , Altomare, C D , Frattaruolo, L , Falcicchio, A , Della Ca', N , Cappello, A R , Gabriele, B (2021)
A stereoselective, multicomponent catalytic carbonylative approach to a new class of α,β-unsaturated γ-lactam derivatives.
Mancuso, R , Ziccarelli, I , Pomelli, C S , Cuocci, C , Della Ca', N , Olivieri, D , Carfagna, C , Gabriele, B (2020)
Unprecedented cooperative DBU-CuCl2 catalysis for the incorporation of carbon dioxide into homopropargylic amines leading to 6-methylene-1,3-oxazin-2-ones.
Pancrazzi, F , Sarti, N , Mazzeo, P P , Bacchi, A , Carfagna, C , Mancuso, R , Gabriele, B , Costa, M , Stirling, A , Della Ca', N (2020)
Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions.
Casnati, A , Voronov, A , Ferrari, D G , Mancuso, R , Gabriele, B , Motti, E , Della Ca', N (2020)
PdI2 as a simple and efficient catalyst for the hydroamination of arylacetylenes with anilines.
Olivieri, Diego, Tarroni, Riccardo, DELLA CA', Nicola, Mancuso, Raffaella, Gabriele, Bartolo, Spadoni, Gilberto, Carfagna, Carla (2020)
Bis-Alkoxycarbonylation of Acrylic Esters and Amides for the Synthesis of 2-Alkoxycarbonyl or 2-Carbamoyl Succinates.
Mancuso, Raffaella, Della Ca’, Nicola, Veltri, Lucia, Ziccarelli, Ida, Gabriele, Bartolo (2019)
PdI2-Based Catalysis for Carbonylation Reactions: A Personal Account.
Gabriele, B , Mancuso, R , Veltri, L , Ziccarelli, I , Della Ca', N (2019)
Palladium-Catalyzed Double Cyclization Processes Leading to Polycyclic Heterocycles: Recent Advances.
Mancuso, R , Milie, R , Palumbo Piccionello, A , Olivieri, D , Della Ca, N , Carfagna, C , Gabriele, B (2019)
Catalytic Carbonylative Double Cyclization of 2-(3-Hydroxy-1-yn-1-yl)phenols in Ionic Liquids Leading to Furobenzofuranone Derivatives.
Casnati, A , Fontana, M , Motti, E , Della Ca, N (2019)
Synthesis of fluorenyl alcohols: Via cooperative palladium/norbornene catalysis.
Casnati, Alessandra, Perrone, Antonio, Mazzeo, Paolo P , Bacchi, Alessia, Mancuso, Raffaella, Gabriele, Bartolo, Maggi, Raimondo, Maestri, Giovanni, Motti, Elena, Stirling, András, DELLA CA', Nicola (2019)
Synthesis of Imidazolidin-2-ones and Imidazol-2-ones via Base-Catalyzed Intramolecular Hydroamidation of Propargylic Ureas under Ambient Conditions.
Casnati, Alessandra, Motti, Elena, Mancuso, Raffaella, Gabriele, Bartolo, Della Ca’, Nicola (2019)
Recent advances in the catalytic synthesis of imidazolidin-2-ones and benzimidazolidin-2-ones.
Mancuso, Raffaella, Ziccarelli, Ida, Fini, Francesco, Della Ca', Nicola, Marino, Nadia, Carfagna, Carla, Gabriele, Bartolo (2019)
A Regio- and Stereoselective Carbonylative Approach to Alkyl (Z)-2-[3-Oxoisobenzofuran-1-(3H)-ylidene]acetates.
Cera, Gianpiero, Della Ca', Nicola, Maestri, Giovanni (2019)
Palladium(0)/benzoic acid catalysis merges sequences with D2O-promoted labelling of C–H bonds.
Dalpozzo, R , Della Ca', N , Gabriele, B , Mancuso, R (2019)
Recent advances in the chemical fixation of carbon dioxide: A green route to carbonylated heterocycle synthesis.
Casnati, A , Motti, E , Mancuso, R , Gabriele, B , Della Ca', N (2019)
Palladium-catalyzed syntheses of fused tricyclic heterocycles: A personal account.
Olivieri, Diego, Fini, Francesco, Mazzoni, Rita, Zacchini, Stefano, Della Ca', Nicola, Spadoni, Gilberto, Gabriele, Bartolo, Mancuso, Raffaella, Zanotti, Valerio, Carfagna, Carla (2018)
Diastereospecific Bis-alkoxycarbonylation of 1,2-Disubstituted Olefins Catalyzed by Aryl α-Diimine Palladium(II) Catalysts.
Mancuso, Raffaella, Ziccarelli, Ida, Chimento, Adele, Marino, Nadia, Della Ca’, Nicola, Sirianni, Rosa, Pezzi, Vincenzo, Gabriele, Bartolo (2018)
Catalytic Double Cyclization Process for Antitumor Agents against Breast Cancer Cell Lines.
Casnati, Alessandra, Fontana, Marco, Coruzzi, Giovanni, Maria Aresta, Brunella, Corriero, Nicola, Maggi, Raimondo, Maestri, Giovanni, Motti, Elena, DELLA CA', Nicola (2018)
Enhancing Reactivity and Selectivity of Aryl Bromides: A Complementary Approach to Dibenzo[b,f]azepine Derivatives.
Acerbi, Alessandra, Carfagna, Carla, Costa, Mirco, Mancuso, Raffaella, Gabriele, Bartolo, Della Ca', Nicola (2018)
An Unprecedented Pd-Catalyzed Carbonylative Route to Fused Furo[3,4-b]indol-1-ones.
Casnati, Alessandra, Gemoets, Hannes P L , Motti, Elena, Della Ca', Nicola, Noël, Timothy (2018)
Homogeneous and Gas–Liquid Catellani-Type Reaction Enabled by Continuous-Flow Chemistry.
Cera, Gianpiero, Lanzi, Matteo, Balestri, Davide, Della Ca', Nicola, Maggi, Raimondo, Bigi, Franca, Malacria, Max, Maestri, Giovanni (2018)
Synthesis of Carbolines via Palladium/Carboxylic Acid Joint Catalysis.
Maffei, Mathias, Giacoia, Gabriele, Mancuso, Raffaella, Gabriele, Bartolo, Motti, Elena, Costa, Mirco, DELLA CA', Nicola (2017)
A highly efficient Pd/CuI-catalyzed oxidative alkoxycarbonylation of α-olefins to unsaturated esters.
Costa, Mirco, Della Ca', , Nicola (2017)
DELLA CA', Nicola, Malacria, Max, Motti, Elena, Maestri, Giovanni (2017)
Palladium- and Norbornene-Catalyzed Synthesis of Highly Functionalized Thiophenes: The Remarkable Effect of Electron-Poor Olefins as Ligand.
Casnati, Alessandra, Maggi, Raimondo, Maestri, Giovanni, Della Ca', Nicola, Motti, Elena (2017)
Pd-Catalyzed/Iodide-Promoted alpha-Arylation of Ketones for the Regioselective Synthesis of Isocoumarins.
Marchegiani, Milena, Nodari, Mirco, Tansini, Fabio, Massera, Chiara, Mancuso, Raffaella, Gabriele, Bartolo, Costa, Mirco, DELLA CA', Nicola (2017)
Urea derivatives from carbon dioxide and amines by guanidine catalysis: Easy access to imidazolidin-2-ones under solvent-free conditions.
Mancuso, Raffaella, Maner, Asif, Ziccarelli, Ida, Pomelli, Christian, Chiappe, Cinzia, Della Ca', Nicola, Veltri, Lucia, Gabriele, Bartolo (2016)
Auto-Tandem Catalysis in Ionic Liquids: Synthesis of 2-Oxazolidinones by Palladium-Catalyzed Oxidative Carbonylation of Propargylic Amines in EmimEtSO4.
Maestri, Giovanni, Cañeque, Tatiana, Della Ca’, Nicola, Derat, Etienne, Catellani, Marta, Chiusoli, Gian Paolo, Malacria, Max (2016)
Pd Catalysis in Cyanide-Free Synthesis of Nitriles from Haloarenes via Isoxazolines.
Della Ca', Nicola, Fontana, Marco, Motti, Elena, Catellani, Marta (2016)
Pd/Norbornene: A Winning Combination for Selective Aromatic Functionalization via C−H Bond Activation.
Mancuso, Raffaella, Raut, Dnyaneshwar S , Della Ca', Nicola, Fini, Francesco, Carfagna, Carla, Gabriele, Bartolo (2015)
Inside Back Cover: Catalytic Oxidative Carbonylation of Amino Moieties to Ureas, Oxamides, 2-Oxazolidinones, and Benzoxazolones (ChemSusChem 13/2015).
DELLA CA', Nicola, Catellani, Marta, Massera, Chiara, Motti, Elena (2015)
Structure and properties of arylnorbornyl palladacycles as stable models for catalytic intermediates.
Queirolo, Michele, Vezzani, Adriano, Mancuso, Raffaella, Gabriele, Bartolo, Costa, Mirco, Della Ca’, Nicola (2015)
Neutral vs anionic palladium iodide-catalyzed carbonylation of terminal arylacetylenes.
Della Ca', Nicola, Fontana, Marco, Xu, Di, Cremaschi, Mirko, Lucentini, Riccardo, Zhou, Zhi-Ming, Catellani, Marta, Motti, Elena (2015)
Formation of a carbonyl group ortho to a biaryl structure or a 6H-dibenzopyran by a palladium/norbornene-catalyzed ordered reaction sequence.
Xu, Di, Dai, Li, Catellani, Marta, Motti, Elena, DELLA CA', Nicola, Zhou, Zhiming (2015)
A novel enantioselective synthesis of 6H-dibenzopyran derivatives by combined palladium/norbornene and cinchona alkaloid catalysis.
Mancuso, Raffaella, Raut, Dnyaneshwar S , Della Ca', Nicola, Fini, Francesco, Carfagna, Carla, Gabriele, Bartolo (2015)
Catalytic oxidative carbonylation of amino moieties to ureas, oxamides, 2-oxazolidinones, and benzoxazolones.
Laura Soldi, Chiara Massera, Mirco Costa, Nicola Della Ca’ (2014)
A novel one-pot synthesis of oxazolidinones through direct introduction of CO2 into allylamine derivatives.
Della Ca', Nicola, Motti, Elena, Catellani, Marta (2014)
Palladium and norbornene catalysis for selective aromatic funcionalization via C-H activation.
Motti, Elena, DELLA CA', Nicola, D , Xu, S , Armani, B M , Aresta, Catellani, Marta (2013)
Competitive pathways in Pd-catalyzed synthesis of arylphenols.
Paolo Bottarelli, Mirco Costa, Nicola Della Ca’, Emanuela Fava (2013)
Ring formation from acyclic precursors: sequential palladium-catalyzed double acetoxylation-cyclization of 3,6-heptadienoates to 2,4-diacetoxycyclopentylideneacetates.
M Catellani, E Motti, N Della Ca', (2013)
Nuove sintesi via palladacicli.
E Motti, N Della Ca', D Xu, A Piersimoni, E Bedogni, Z -M Zhou, M Catellani (2012)
A Sequential Pd/Norbornene-Catalyzed Process Generateso-Biaryl Carbaldehydes or Ketones via a Redox Reaction or 6H-Dibenzopyrans by C–O Ring Closure.
Maestri, Giovanni, Motti, Elena, DELLA CA', Nicola, M , Malacria, E , Derat, Catellani, Marta (2011)
Of the Ortho Effect in Palladium/Norbornene-Catalyzed Reactions: A Theoretical Investigation.
N Della Ca', G Maestri, M Malacria, E Derat, M Catellani (2011)
Palladium-Catalyzed Reaction of Aryl Iodides with ortho-Bromoanilines and Norbornene/Norbornadiene: Unexpected Formation of Dibenzoazepine Derivatives.
DELLA CA', Nicola, Bottarelli, Paolo, A , Dibenedetto, M , Aresta, B , Gabriele, G , Salerno, Costa, Mirco (2011)
Palladium-catalyzed synthesis of symmetrical urea derivatives by oxidative carbonylation of primary amines in carbon dioxide medium.
N Della Ca', B Gabriele, G Ruffolo, L Veltri, T Zanetta, M Costa (2011)
Effective Guanidine-Catalyzed Synthesis of Carbonate and Carbamate Derivatives from Propargyl Alcohols in Supercritical Carbon Dioxide.
Motti, Elena, DELLA CA', Nicola, Deledda, S , Fava, E , Panciroli, F , Catellani, Marta (2010)
Palladium-catalyzed unsymmetrical aryl couplings in sequence leading to o-teraryls: dramatic olefin effect on selectivity.
DELLA CA', Nicola, Motti, Elena, Mega, Antonio, Catellani, Marta (2010)
One-pot Palladium-Catalyzed Synthesis of Selectively Substituted Phenanthridines by Sequential Aryl-Aryl and Heck Couplings, aza-Michael and retro-Mannich Reactions.
Chiusoli, Gian Paolo, Catellani, Marta, Costa, Mirco, Motti, Elena, DELLA CA', Nicola, Maestri, Giovanni (2010)
Catalytic C–C coupling through C–H arylation of arenes or heteroarenes.

Temi di ricerca

Il lavoro del Prof. Della Ca’ ha avuto un considerevole impatto nell’ambito della catalisi, ed in particolare ha contribuito ad importanti avanzamenti nei seguenti campi di ricerca:

A) Sviluppo di metodologie di attivazione del legame C-H mediante palladacicli (Catellani Reactions);

B) Sviluppo di protocolli di sintesi di molecole ad alto valore aggiunto;

C) Sviluppo di protocolli innovativi di carbonilazione per la sintesi di prodotti di interesse farmaceutico/industriale;

D) Sviluppo di nuovi metodi di fissazione di diossido di carbonio basati sull’utilizzo di organo catalizzatori.


A) Esempio di reazione di Catellani per l'ottenimento di sistemi triciclici condensati:


B) Esempio di reazione catalizzata dal palladio per l'ottenimento di ammine secondarie:


C) Esempio di reazione di carbonilazione catalizzata dal palladio per l'ottenimento di derivati ad elevata complessità:


D) Esempio di reazione catalizzata da basi forti (guanidine) per l'ottenimento di imidazolidinoni a partire da ammine e CO2:


Gruppi di ricerca

Progetti di ricerca


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