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Prof. Andrea Sgoifo

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PRESENT RESEARCH ACTIVITY

Research activity in the Stress Physiology Lab is mainly focused on the biological substrates of depression/anxiety and autonomic/cardiovascular dysfunction comorbidity. This topic is approached via preclinical research on animal models of depression (based on adverse social conditions) and anxiety (based on lines selectively bred). Proendocannabinoid pharmacological treatment (FAAH inhibition) is tested to verify its pevention/reversal potential over behavioral and physiological symptoms of anxiety/depression as well as over autonomic/cardiovascular dysfunction. Part of the lab research activity is also devoted to the evaluation of a number of chronic stress parameters in various human populations. Ongoing collaborations: (a) Dept of Behavioral Physiology – Univ. Groningen (NL; profs. S. De Boer and P. Meerlo), (b) School of Biomedical Sciences & Pharmacy – Univ. Newcastle (AUS; prof. E. Nalivaiko), (c) Dept. of Neurobiology and Animal Physiology – Univ. Regensburg (GER; prof. I. Neumann), (d) Dept. of Psychology – NWU Chicago (USA; prof. A. Grippo), (e) Dept. of Pharmacy – Univ. of Parma (IT; profs. M. Mor and S. Rivara), (f) Dept. of Medicine & Surgery – Univ. of Parma (IT; prof. P.F. Ferrari)

RESEARCH KEY WORDS

Stress, chronic social stress, biological stress markers, anxiety, depression, coping styles, social behavior, hypothalamic-pituitary-adrenocortical axis, sympathetic-adrenomedullary system, autonomic nervous system, heart rate variability, cardiovascular physiology and pathophysiology, arrhythmias, rodent model of empathy

 

Prodotti della ricerca

 ARTICLES in INTERNATIONAL PEER-REVIEWED JOURNALS  2013-2017  (Impact Factor 2015)

 2017

- Carnevali L, Montano N, Statello R, Sgoifo ARodent models of depression-cardiovascular comorbidity: Bridging the known to the new. Neurosci Biobehav Rev. 2017 Jan 16. pii: S0149-7634(16)30449-3. doi: 10.1016/j.neubiorev.2016.11.006. (i..f.: 8.58)

- Villada C, Espin L, Hidalgo V, Rubagotti S, Sgoifo A, Salvador A. The influence of coping strategies and behavior on the physiological response to social stress in women: The role of age and menstrual cycle phase. Physiology & Behavior 2017 Mar 1;170:37-46. doi: 10.1016/j.physbeh.2016.12.011. (2.46)

 2016

- Rossi S, Buccarello A, Ershler PR, Lux RL, Callegari S, Corradi D, Carnevali L, Sgoifo A, Miragoli M, Musso E, Macchi E. Effect of anisotropy on ventricular vulnerability to unidirectional block and reentry by single premature stimulation during normal sinus rhythm in rat heart. Am J Physiol Heart Circ Physiol. 2016 Dec 23:ajpheart.00366.2016. doi: 10.1152/ajpheart.00366.2016. (3.32)

- Sgoifo A, Montano N, Esler M, Vaccarino V. Stress, behavior and the heart. Neurosci Biobehav Rev. 2016 Nov 9. pii: S0149-7634(16)30669-8. doi: 10.1016/j.neubiorev.2016.11.003. (8.58)

- Carnevali L, Andrews PL, Neumann ID, Nalivaiko E, Sgoifo AAutonomic changes induced by provocative motion in rats bred for high (HAB) and low (LAB) anxiety-related behavior: Paradoxical responses in LAB animals. Physiology & Behavior 2016 Dec 1;167:363-373. doi: 10.1016/j.physbeh.2016.09.028. (2.46)

- Statello R, Carnevali L, Paterlini S, Gioiosa L, Bertocchi I, Oberto A, Eva C, palanza P, Sgoifo A. Reduced NPY Y1 receptor hippocampal expression and signs of decreased vagal modulation of heart rate in mice. Physiology & Behavior, S0031-9384(16)30575-3, 2016 (2.46)

- Carnevali L, Rivara S, Nalivaiko E, Thayer JF, Vacondio F, Mor M, Sgoifo A. Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological – cardiac comorbidity? Neuroscience & Biobehavioral Reviews, S0149-7634(16)30031-8, 2016 (8.58)

- Walker FR, Pfingst K, Carnevali L, Sgoifo A, Nalivaiko E. In the search for an integrative biomarker of resilience to psychological stress. Neuroscience & Biobehavioral Reviews, S0149-7634(15)30360-2, 2016 (8.58)

 2015

- Carnevali L, Vacondio F, Rossi S, Macchi E, Spadoni G, Bedini A, Neumann ID, Rivara S, Mor M, Sgoifo A. Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety. Scientific Reports 5:182182015 (5.23)

- Carnevali L, Vacondio F, Rossi S, Callegari S, Macchi E, Spadoni G, Bedini A, Rivara S, Mor M, Sgoifo A. Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats. European Neuropsychopharmacology 25(11):2157-69,2015 (4.41)

Sgoifo A, Carnevali L, Pico-Alfonso MA, Amore M. Autonomic dysfunction and heart rate variability in depression. Stress-The International Journal on the Biology of Stress, 25:1-10, 2015 (2,38)

 2014

- Ponzi D, Muehlenbein PM, Sgoifo A, Geary DC, Flinn MV. Day-to-day variation of salivary cortisol and dehydroepiandrosterone (DHEA) in children from a rural Dominican community. Adaptive Human Behavior and Physiology, 1:4-16, 2014 (0)

- Villada C, Hidalgo V, Almela M, Mastorci F, Sgoifo A, Salvador A. Coping with an acute psychosocial challenge: behavioral and physiological responses in young women.PLoS ONE, 9(12):e114640, 2014 (3.06)

- Rossi S, Fortunati I, Carnevali L, Baruffi S, Mastorci F, Trombini M, Sgoifo A, Corradi D, Callegari S, Miragoli M, Macchi E. The effect of aging on the specialized conducting system: a telemetry ECG study in rats over a 6 month period. PLoS ONE, 9(11):e112697, 2014 (3.06)

- Carnevali L, Nalivaiko E, Sgoifo A. Respiratory patterns reflect different levels of emotionality in wild type rats. Respiratory Physiology & Neurobiology, 204:28-35, 2014 (1.77)

- Carnevali L, Sgoifo A. Vagal modulation of resting heart rate in rats: the role of stress, psychosocial factors, and physical exercise. Frontiers in Physiology, 5:118, 2014 (4.03)

- Carnevali L, Graiani G, Rossi S, Al Banchaabouchi M, Macchi E, Quaini F, Rosenthal N, Sgoifo A. Signs of cardiac autonomic imbalance and proarrhythmic remodeling in FTO deficient mice. PLoS ONE, 9(4):e95499, 2014 (3.06)

- Carnevali L, Trombini M, Graiani G, Madeddu D, Quaini F, Landgraf R, Neumann ID, Nalivaiko E, Sgoifo A. Low vagally-mediated heart rate variability and increased susceptibility to ventricular arrhythmias in rats bred for high anxiety. Physiology & Behavior 128:16-25, 2014 (2,46)

Sgoifo A, Carnevali L, Grippo AJ. The socially stressed heart. Insights from studies in rodents. Neuroscience & Biobehavioral Reviews 39:51-60, 2014 (8.58)

 2013

- Carnevali L, Trombini M, Porta A, Montano N, de Boer SF, Sgoifo A. Vagal withdrawal and susceptibility to cardiac arrhythmias in rats with high trait aggressiveness. PLoS One 8(7):e68316, 2013 (3.06)

- Carnevali L, Sgoifo A, Trombini M, Landgraf R, Neumann ID, Nalivaiko E. Different patterns of respiration in rat lines selectively bred for high or low anxiety. PLoS One2013, 8(5):e64519 (3.06)

- Carnevali L, Trombini M, Rossi S, Graiani G, Manghi M, Koolhaas JM, Quaini F, Macchi E, Nalivaiko E, Sgoifo A. Structural and electrical myocardial remodeling in a rodent model of depression. Psychosomatic Medicine, 75(1):42-51, 2013 (3.64)

 

Ricevimento studenti

Venerdý 9.30-11.00

Membro del Comitato 105

Ultimo aggiornamento: 18/02/2017 15:38
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