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Laboratorio di Fisiopatologia Cardiaca

Cardiomyocytes

Componenti

Contatti

Settore ERC

LS2_11 - Computational biology
LS3_5 - Cell differentiation, physiology and dynamics
LS4_7 - Cardiovascular diseases

Attivitą

TEMI DI RICERCA

Studio delle modificazioni strutturali e funzionali del cuore nelle fasi iniziali del diabete (a livello d'organo, cellulare e molecolare) e della loro progressione fino al manifestarsi fenotipico della cardiomiopatia.

Analisi del contributo relativo dei cardiomiociti e dei fibroblasti cardiaci nell'indurre modificazioni del microambiente tissutale.

Ruolo cardioprotettivo e meccanismi d'azione di composti polifenolici naturali introdotti con la dieta.

Meccanismi di ripolarizzazione del potenziale d'azione cellulare cardiaco e la loro modulazione elettrofisiologica e farmacologica. 

 

 RESEARCH TOPICS

Cardiac morpho-functional changes progressively leading towards ventricular dysfunction, in rat models of diabetes.

Analysis of spontaneous compensatory mechanisms aimed at preserving cardiac electromechanical performance at early stages of diabetes, with specific attention to the role of cardiac stem cell compartment.

Evaluation of the biological activity of the most relevant phenolics of plant food origin, with particular reference to their mechanisms of action in the framework of cardiovascular complications and diabetes onset using in-vivo (animal) and in-vitro approaches.

Repolarization mechanisms of cardiac cellular action potential and their electrophysiological and pharmacological modulation. 

Prodotti della ricerca

Savi, Monia, Bocchi, Leonardo, Sala, Roberto, Frati, Caterina, Lagrasta, Costanza, Madeddu, Denise, Falco, Angela, Pollino, Serena, Bresciani, Letizia, Miragoli, Michele, Zaniboni, Massimiliano, Quaini, Federico, Del Rio, Daniele, Stilli, Donatella (2016)
Parenchymal and Stromal Cells Contribute to Pro-Inflammatory Myocardial Environment at Early Stages of Diabetes: Protective Role of Resveratrol.
https://air.unipr.it/handle/11381/2818307

Miragoli, Michele, Rossi, Stefano, Savi, Monia, Goldoni, Matteo, Pinelli, Silvana, Alinovi, Rossella, Galetti, Maricla, Stilli, Donatella, Macchi, Emilio, Zaniboni, Massimiliano, Mutti, Antonio (2016)
Esposizione a nanoparticelle: Studi in-vitro ed in-vivo per valutare i fattori di rischio cardiovascolari in cuori normali e patologici.
https://air.unipr.it/handle/11381/2820190

Savi, Monia, Bocchi, Leonardo, Rossi, Stefano, Frati, Caterina, Graiani, Gallia, Lagrasta, Costanza, Miragoli, Michele, Pasquale, Elisa Di, Stirparo, Giuliano G , Mastrototaro, Giuseppina, Urbanek, Konrad, Angelis, Antonella De, Macchi, Emilio, Stilli, Donatella, Quaini, Federico, Musso, Ezio (2016)
Antiarrhythmic effect of growth factor-supplemented cardiac progenitor cells in chronic infarcted heart.
https://air.unipr.it/handle/11381/2809721

Sala, Roberto, Mena, Pedro, Savi, Monia, Brighenti, Furio, Crozier, Alan, Miragoli, Michele, Stilli, Donatella, Del Rio, Daniele (2015)
Urolithins at physiological concentrations affect the levels of pro-inflammatory cytokines and growth factor in cultured cardiac cells in hyperglucidic conditions.
https://air.unipr.it/handle/11381/2787091

Savi, Monia, Bocchi, Leonardo, Fiumana, Emanuela, Karam, Jean-Pierre, Frati, Caterina, Bonafé, Francesca, Cavalli, Stefano, Morselli, Paolo G , Guarnieri, Carlo, Caldarera, Claudio M , Muscari, Claudio, Montero-Menei, Claudia N , Stilli, Donatella, Quaini, Federico, Musso, Ezio (2015)
Enhanced engraftment and repairing ability of human adipose-derived stem cells, conveyed by pharmacologically active microcarriers continuously releasing HGF and IGF-1, in healing myocardial infarction in rats.
https://air.unipr.it/handle/11381/2809723

M Savi, L Bocchi, E Fiumana, C Frati, F Bonafé, S Cavalli, P G Morselli, J P Karam, C Montero-Menei, C M Caldarera, C Guarnieri, C Muscari, D Stilli, F Quaini, E Musso (2014)
Cardiac regeneration by pharmacologically active microcarriers releasing growth factors and/or transporting adipose-derived stem cells.
https://air.unipr.it/handle/11381/2679684

Bresciani L, Calani L, Bocchi L, Delucchi F, Savi M, Ray S, Brighenti F, Stilli D, Del Rio D (2014)
Bioaccumulation of Resveratrol Metabolites in Myocardial Tissue is Dose-Time Dependent and Related to Cardiac Hemodynamics in Diabetic Rats.
https://air.unipr.it/handle/11381/2645663

Savi, Monia, Rossi, Stefano, Bocchi, Leonardo, Gennaccaro, Laura, Cacciani, Francesca, Perotti, Alessio, Amidani, Davide, Alinovi, Rossella, Goldoni, Matteo, Aliatis, Irene, Lottici, Pier, Bersani, Danilo, Campanini, Marco, Pinelli, Silvana, Petyx, Marta, Frati, Caterina, Gervasi, Andrea, Urbanek, Konrad, Quaini, Federico, Buschini, Annamaria, Stilli, Donatella, Rivetti, Claudio, Macchi, Emilio, Mutti, Antonio, Miragoli, Michele, Zaniboni, Massimiliano (2014)
Titanium dioxide nanoparticles promote arrhythmias via a direct interaction with rat cardiac tissue.
https://air.unipr.it/handle/11381/2784194

M Savi, L Bocchi, L Gennaccaro, S Rossi, A Perotti, D Amidani, A Buschini, C Rivetti, F Cacciani, E Macchi, M Miragoli, D Stilli, M Zaniboni (2013)
Effects of acute exposure to titanium dioxide (TiO2) nanoparticles on ventricular cardiomyocytes: mechanical and cytotoxic characterization.
https://air.unipr.it/handle/11381/2679685

L Bocchi, S Rossi, M Savi, L Gennaccaro, F Cacciani, D Stilli, E Macchi, M , , Miragoli, M Zaniboni (2013)
Cardiac effects of acute exposure to titanium dioxide nanoparticles: electrophysiological characterization.
https://air.unipr.it/handle/11381/2650863

M Savi, L Bocchi, E Fiumana, C Frati, F Bonafé, S Cavalli, P G Morselli, J -P Karam, C Monteo-Menei, C M Caldarera, C Guarnieri, C Muscari, D Stilli, F Quaini, E Musso (2012)
Cardiac regeneration by pharmacologically active microcarriers releasing growth factors and/or transporting adipose-derived stem cells.
https://air.unipr.it/handle/11381/2563445

F Delucchi, R Berni, C Frati, S Cavalli, G Graiani, R Sala, C Chaponnier, G Gabbiani, L Calani, D Del Rio, L Bocchi, C Lagrasta, F Quaini, D Stilli (2012)
Resveratrol Treatment Reduces Cardiac Progenitor Cell Dysfunction and Prevents Morpho-Functional Ventricular Remodeling in Type-1 Diabetic Rats.
https://air.unipr.it/handle/11381/2433851

Francesca Delucchi, Roberta Berni, Caterina Frati, Stefano Cavalli, Gallia Graiani, Roberto Sala, Christine Chaponnier, Giulio Gabbiani, Luca Calani, Daniele Del Rio, Leonardo Bocchi, Costanza Lagrasta, Federico Quaini, Donatella Stilli (2012)
Resveratrol treatment reduces cardiac Progenitor cell dysfunction and prevents morpho-functional ventricular remodeling in type-1 diabetic rats.
https://air.unipr.it/handle/11381/2634658

C Frati, M Savi, G Graiani, C Lagrasta, S Cavalli, L Prezioso, P Rossetti, C Mangiaracina, F Ferraro, D Madeddu, E Musso, D Stilli, A Rossini, A Falco, A De Angelis, F Rossi, K Urbanek, A Leri, J Kajstura, P Anversa, E Quaini, F Quaini (2011)
Resident cardiac stem cells.
https://air.unipr.it/handle/11381/2386992

Bocchi L, Savi M, Graiani G, Rossi S, Agnetti A, Stillitano F, Lagrasta C, Baruffi S, Berni R, Frati C, Vassalle M, Squarcia U, Cerbai E, Macchi E, Stilli D, Quaini F, Musso E (2011)
Growth factor-induced mobilization of cardiac progenitor cells reduces the risk of arrhythmias, in a rat model of chronic myocardial infarction.
https://air.unipr.it/handle/11381/2362757

C Colussi, J Rosati, S Straino, F Spallotta, R Berni, D Stilli, S Rossi, E Musso, E Macchi, A Mai, G Sbardella, S Castellano, C Chimenti, A Frustaci, A Nebbioso, L Altucci, M C Capogrossi, C Gaetano (2011)
N?-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart.
https://air.unipr.it/handle/11381/2384888

Frati C, Savi M, Graiani G, Lagrasta C, Cavalli S, Prezioso L, Rossetti P, Mangiaracina C, Ferraro F, Madeddu D, Musso E, Stilli D, Rossini A, Falco A, Angelis AD, Rossi F, Urbanek K, Leri A, Kajstura J, Anversa P, Quaini E, Quaini F (2011)
Resident cardiac stem cells.
https://air.unipr.it/handle/11381/2374096

L Prezioso, S Tanzi, F Galaverna, C Frati, B Testa, M Savi, S Graiani, C Lagrasta, S Cavalli, S Galati, D Madeddu, E Lodi Rizzini, F Ferraro, E Musso, D Stilli, K Urbanek, E Piegari, A De Angelis, A Maseri, F Rossi, E Quaini, F Quaini (2010)
Cancer treatment-induced cardiotoxicity: a cardiac stem cell disease?
https://air.unipr.it/handle/11381/2304648

C Colussi, R Berni, J Rosati, S Straino, S Vitale, F Spallotta, S Baruffi, L Bocchi, F Delucchi, S Rossi, M Savi, D Rotili, F Quaini, E Macchi, D Stilli, E Musso, A Mai, C Gaetano, M C Capogrossi (2010)
The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice.
https://air.unipr.it/handle/11381/2304629

Quaini F, Bocchi L, Savi M, Berni R, Delucchi F, Frati C, Lagrasta C, Stilitano F, Agnetti A, Baruffi S, Rossi S, Squarcia UC, Cerbai E, Macchi E, Stilli D, Musso E (2009)
Mobilization of cardiac progenitor cells by Hepatocyte Growth Factor (HGF) and Insulin-like Growth Factor-1 (IGF-1) for repairing chronic myocardial infarction (MI) is not proarrhytmic.
https://air.unipr.it/handle/11381/2306774

Bocchi L, Savi M, Berni R, Delucchi F, Frati C, Graiani G, Lagrasta C, Stillitano F, Agnetti A, Baruffi S, Rossi S, Squarcia U, Cerbai E, Macchi E, Stilli D, Quaini F, Musso E (2009)
Repair of chronic myocardial infarction (MI) induced by mobilization of cardiac progenitor cells (CPCs) via local delivery of hapatocyte growth factor (HGF) and insulin-like growth factor-1 (IGF-1) is not proarrhythmic.
https://air.unipr.it/handle/11381/2306770

R Berni, M Savi, L Bocchi, F Delucchi, E Musso, C Chaponnier, G Gabbiani, S Clement, D Stilli (2009)
Modulation of actin isoform expression before the transition from experimental compensated pressure-overload cardiac hypertrophy to decompensation.
https://air.unipr.it/handle/11381/2304955

Delucchi F, Berni R, Savi M , Bocchi L , Musso E , Gabbiani G , Clement S , Stilli D (2009)
Changes in actin isoform expression prior to the transition from compensated pressure-overload cardiac hypertrophy to decompensation.
https://air.unipr.it/handle/11381/2306772

Delucchi F, Colussi C, Berni R, Rosati J, Straino S, Spallotta F, Bocchi L, Savi M, Macchi E, Stilli D, Quaini F, Capogrossi MC, Gaetano C, Musso E (2009)
Hystone deacetylase inhibitors (HDACi) ameliorate cardiac elctrical competence in mdx mouse model of Duchenne muscular dystrophy (DMD).
https://air.unipr.it/handle/11381/2306771

BERNI R, SAVI M, BOCCHI L, DELUCCHI F, MUSSO E, CHAPONNIER C, GABBIANI G, CLEMENT S, STILLI D (2009)
Modulation of actin isoform expression before the transition from experimental compensated pressure-overload cardiac hypertrophy to decompensation.
https://air.unipr.it/handle/11381/1960205

Quaini F, Graiani G, Lagrasta C, Savi M, Bocchi L, Frati C, Testa B, Berni R, Vassalle M, Stilli D, Musso E (2008)
Electromechanical competence of the myocardium regenerated by growth factors and cell therapy in ischemic cardiomyopathy.
https://air.unipr.it/handle/11381/2306777

Berni R, Colussi C, Bocchi L, Savi M, Delucchi F, Quaini F, Stilli D, Musso E, Gaetano C (2008)
Deacetylase Inhibitors ameliorate cardiac electrical competence in MDX mouse model of Duchenne muscular dystrophy (DMD).
https://air.unipr.it/handle/11381/2306775

Stilli D, Lagrasta C, Berni R, Bocchi L, Savi M, Delucchi F, Graiani G, Baruffi S, Macchi E, Quaini F (2008)
Cardiac stem cell disease in diabetic cardiomyopathy: perspectives for preventing cardiac morpho-functional remodelling.
https://air.unipr.it/handle/11381/2306776

Berni R, Colussi C, Bocchi L, Savi M, Delucchi F, Quaini F, Stilli D, Musso E, Gaetano C (2008)
Deacetylase inhibitors reduce cardiac arrhythmogenesis in mdx mouse model of duchenne muscular dystrophy (DMD).
https://air.unipr.it/handle/11381/2306790

Colussi C, Berni R, Bocchi L, Savi M, Delucchi F, Stilli D, Quaini F, Musso E, Caporossi MC, Gaetano C (2008)
Histone deacetylase inhibitors ameliorate cardiac electrical competence in dystrophic mice.
https://air.unipr.it/handle/11381/2306908

Savi M, Frati C, Bocchi L, Graiani G, Berni R, Lagrasta C, Stilli D, Quaini F, Vassalle M, Musso E (2008)
Electrical stability of infarcted rat hearts following treatment with stem cells.
https://air.unipr.it/handle/11381/2306748

STILLI D, LAGRASTA C, BERNI R, BOCCHI L, SAVI M, DELUCCHI F, GRAIANI G, MONICA M, MAESTRI R, BARUFFI S, ROSSI S , MACCHI E, MUSSO E, QUAINI F (2007)
Preservation of ventricular performance at early stages of diabetic cardiomyopathy involves changes in myocyte size, number and intercellular coupling.
https://air.unipr.it/handle/11381/1644639

STILLI D , BOCCHI L, BERNI R, ZANIBONI M, CACCIANI F, CHAPONNIER C, MUSSO E, GABBIANI G, CLEMENT S (2006)
Correlation of {alpha}-skeletal actin expression, ventricular fibrosis and heart function with the degree of pressure overload cardiac hypertrophy in rats.
https://air.unipr.it/handle/11381/2295806

BERNI R, CACCIANI F, ZANIBONI M , SAVI M, BOCCHI L, LAPUCCI S, RAZZETTI R, PASTORE F, MUSSO E, STILLI D (2006)
Effects of the alpha2-adrenergic/DA2-dopaminergic agonist CHF-1024 in preventing ventricular arrhythmogenesis and myocyte electrical remodeling, in a rat model of pressure-overload cardiac hypertrophy.
https://air.unipr.it/handle/11381/1493613

SAVI M, BOCCHI L, BERNI R , GRAIANI G, LAGRASTA C, AGNETTI A, BARUFFI S, ROSSI S, BERTUZZI A, SQUARCIA U, MACCHI E, QUAINI F, STILLI D, MUSSO E (2006)
Electro-mechanical competence of regenerated heart in stem cell based therapy of myocardial infarction in rat model.
https://air.unipr.it/handle/11381/1647079

Urbanek, Konrad, Frati, Caterina, Graiani, Gallia, Madeddu, Denise, Falco, Angela, Cavalli, Stefano, Lorusso, Bruno, Gervasi, Andrea, Prezioso, Lucia, Savi, Monia, Ferraro, Francesca, Galaverna, Federica, Rossetti, Pietro, Lagrasta, Costanza Annamaria, Fancesca, R E, Quaini, Eugenio, Rossi, Francesco, Angelis, Antonella De, Quaini, Federico (2015)
Cardioprotection by Targeting the Pool of Resident and Extracardiac Progenitors.
https://air.unipr.it/handle/11381/2794655

F Bianchi, E Caffarri, S Cavalli, C Lagrasta, M Musci, F Quaini, M Savi (2013)
Development and validation of an high performance liquidchromatography?tandem mass spectrometry method for the determination of imatinib in rat tissues.
https://air.unipr.it/handle/11381/2429240

C Frati, A Falco, A Gervasi, G Graiani, B Lorusso, D Madeddu, M Savi, S Cavalli, A De Angelis, E Piegari, K Urbanek, F Rossi, F Galaverna, L Prezioso, C Lagrasta, F Quaini (2013)
Dissecting the cellular mechanisms of cardiotoxicity by anthracycline and tyrosine kinase inhibitors.
https://air.unipr.it/handle/11381/2655466

A Giuliani, C Frati, A Rossini, VS Komlev, C Lagrasta, M Savi, S Cavalli, C Gaetano, F Quaini, A Manescu, F Rustichelli (2011)
High-resolution X-ray microtomography for three-dimensional imaging of cardiac progenitor cell homing in infarcted rat hearts.
https://air.unipr.it/handle/11381/2393327

A Falco, S Cavalli, B Lorusso, M Savi, C Frati, D Maselli, D Moschettini, M Cimini, F Quaini, C Lagrasta (2011)
Role of cardiac lymphatic vessels in ischemic and drug induced cardiomyopathy.
https://air.unipr.it/handle/11381/2393335

D Madeddu, C Frati, G Graiani, L Prezioso, S Cavalli, C Mangiaracina, M Savi, B Lorusso, C Lagrasta, F Quaini (2011)
Lymphangiogenesis in genetically determined hypertrophic obstructive cardiomyopathy.
https://air.unipr.it/handle/11381/2393336

D Madeddu, C Mangiaracina, S Cavalli, C Frati, G Graiani, L Prezioso, M Savi, B Lorusso, A Falco, F Quaini (2010)
Potential involvement of cardiac and bone marrow vascular progenitors in imatinib induced cardiovascular toxicity.
https://air.unipr.it/handle/11381/2393332

S Cavalli, M Cimini, S Galati, M Lazzaretti, M Savi, C Frati, L Prezioso, G Graiani, C Lagrasta, D Madeddu, F Galaverna, C Mangiaracina, A Falco, B Lo Russo, F Ferraro, F Quaini (2010)
L?autofagia coinvolge i cardiomiociti e le cellule progenitrici nella cardiomiopatia indotta da imatinib mesilato.
https://air.unipr.it/handle/11381/2393330

M Savi (2010)
Stem cell based regenerative therapies in healed myocardial infarction.
https://air.unipr.it/handle/11381/2393328

A Giuliani, C Frati, A Rossini, V S Komlev, S Cavalli, C Lagrasta, M Savi, M C Capogrossi, A Manescu, F Quaini, F Rustichelli (2010)
High-Resolution X-Ray Microtomography for Three-Dimensional Visualization of Cardiac Progenitor Cells Homing in Infarcted Rat Hearts.
https://air.unipr.it/handle/11381/2393329

M Cimini, S Cavalli, M Savi, C Frati, L Prezioso, F Galaverna, G Graiani, D Madeddu, S Galati, C Lagrasta (2010)
Tyrosine kinase cardiotoxicity: ultrastructural analysis of imatinib mesylate induced cardiomyopathy.
https://air.unipr.it/handle/11381/2393331

C Frati, A Rossini, A Giuliani, V Komlev, C Lagrasta, M Savi, MC Capogrossi, F Quaini, A Manescu, F Rustichelli (2009)
High-resolution X-ray microtomography for three-dimensional visualization of Cardiac Progenitor Cells Homing in infarcted rat hearts.
https://air.unipr.it/handle/11381/2306789

L Prezioso, M Savi, C Frati, S Tanzi, F Galaverna, C Lagrasta, S Cavalli, S Galati, E Musso, F Quaini (2009)
Imatinib mesylate induced cardiotoxicity: a cardiac progenitor cell disease?
https://air.unipr.it/handle/11381/2306788

L Prezioso, F Galaverna, S Tanzi, C Frati, M Savi, C Lagrasta, S Cavalli, S Galati, F Ferraro, A De Angelis, E Piegari, F Rossi, V Rizzoli, F Quaini (2009)
Imatinib Mesylate Induced Cardiotoxicity: a Cardiac Progenitor Cell Disease?
https://air.unipr.it/handle/11381/2306889

Mario Vassalle, Leonardo Bocchi (2013)
Differences in ionic currents between canine myocardial and Purkinje cells.
https://air.unipr.it/handle/11381/2645462

BOCCHI L , VASSALLE M (2008)
Characterization of the slowly inactivating sodium current INa2 in canine cardiac single purkinje cells.
https://air.unipr.it/handle/11381/2306888

VASSALLE M, BOCCHI L , FUYONG DU (2007)
A slowly inactivating sodium current (INa2) in the plateau range in canine cardiac purkinje single cells.
https://air.unipr.it/handle/11381/1645001

Ultimo aggiornamento: 14/06/2017 11:25
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